Recent Publications

  1. Baer MH*, Cascarina SM*, Paul KR*, Ross ED. Rational tuning of the concentration-independent enrichment of prion-like domains in stress granules. J Mol Biol 2024.  Pubmed  *Co-first authors
  2. Cascarina SM, Ross ED. Identification of low-complexity domains by compositional signatures reveals class-specific frequencies and functions across the domains of life. PLOS Comput Biol 2024.  Pubmed  Download PDF
  3. Cascarina SM, Ross ED. The LCD-Composer webserver: high-specificity identification and functional analysis of low-complexity domains in proteins. Bioinformatics 2022.  Pubmed  Download PDF
  4. Cascarina SM, Ross ED. Expansion and functional analysis of the SR-related protein family across the domains of life. RNA 2022.  Pubmed  Download PDF
  5. Cascarina SM, Ross ED. Phase separation by the SARS-CoV-2 nucleocapsid protein: consensus and open questions. JBC 2022.  Pubmed  Download PDF
  6. Cascarina SM, Kaplan JP, Elder MR, Brookbank L, Ross ED. Generalizable compositional features influencing the proteostatic fates of polar low-complexity domains. IJMS 2021.  Pubmed  Download PDF
  7. Cascarina SM, King DC, Osborne Nishimura E, Ross ED. LCD-Composer: an intuitive, composition-centric method enabling the identification and detailed functional mapping of low-complexity domains. NAR Genom & Bioinform 2021.  Pubmed  Download PDF
  8. Fomicheva A, Ross ED. From prions to stress granules: defining the compositional features of prion-like domains that promote different types of assemblies. IJMS 2021.  Pubmed  Download PDF
  9. Cascarina SM, Ross ED. A proposed role for the SARS-CoV-2 nucleocapsid protein in the formation and regulation of biomolecular condensates. FASEB J 2020.  Pubmed  Download PDF
  10. Boncella AE*, Shattuck JE*, Cascarina SM, Paul KR, Baer MH, Fomicheva A, Lamb AK, Ross ED. Composition-based prediction and rational manipulation of prion-like domain recruitment to stress granules. Proc Nat Acad Sci 2020.  Pubmed  Download PDF  *Co-first authors
  11. Cascarina SM, Elder MR, Ross ED. Atypical structural tendencies among low-complexity domains in the Protein Data Bank proteome. PLOS Comput Biol 2020.  Pubmed  Download PDF
  12. Cascarina SM, Ross ED. Natural and pathogenic protein sequence variation affecting prion-like domains within and across human proteomes. BMC Genom 2020.  Pubmed  Download PDF
  13. Shattuck JE, Cascarina SM, Paul KR, Ross ED. Sky1: at the intersection of prion-like proteins and stress granule regulation. Curr Genet 2020. Pubmed
  14. Shattuck JE, Paul KR, Cascarina SM, Ross ED. The prion-like protein kinase Sky1 is required for efficient stress granule disassembly. Nat Commun 2019.  Pubmed  Download PDF
  15. Cascarina SM, Ross ED. Aggregation and degradation scales for prion-like domains: sequence features and context weigh in. Curr Genet 2019.  Pubmed
  16. Cascarina SM, Ross ED. Proteome-scale relationships between local amino acid composition and protein fates and functions. PLOS Comput Biol 2018.  Pubmed  Download PDF
  17. Cascarina SM, Paul KR, Machihara S, Ross ED. Sequence features governing aggregation or degradation of prion-like proteins. PLOS Genet 2018.  Pubmed  Download PDF
  18. Cascarina SM, Paul KR, Ross ED. Manipulating the aggregation activity of human prion-like proteins. Prion 2017.  Pubmed
  19. Shattuck JE, Waechter AC, Ross ED. The effects of glutamine/asparagine content on aggregation and heterologous prion induction by yeast prion-like domains. Prion 2017.  Pubmed
  20. Afsar Minhas F ul A, Ross ED, Ben-Hur A. Amino acid composition predicts prion activity. PLOS Comput Biol 2017.  Pubmed  Download PDF
  21. Paul KR, Molliex A, Cascarina S, Boncella AE, Taylor J, Ross ED. Effects of mutations on the aggregation propensity of the human prion-like protein hnRNPA2B1. Mol Cell Biol 2017.  Pubmed

Select Prior Publications

  1. Paul KR, Hendrich CG, Waechter A, Harman MR, Ross ED. Generating new prions by targeted mutation or segment duplication. Proc Natl Acad Sci 2015.  Pubmed  Download PDF
  2. Gonzalez Nelson AC, Paul KR, Petri M, Flores N, Rogge RA, Cascarina SM, Ross ED. Increasing prion propensity by hydrophobic insertion. PLOS One 2014.  Pubmed  Download PDF
  3. Cascarina SM, Ross ED. Yeast prions and human prion-like proteins: sequence features and prediction methods. Cell Mol Life Sci 2014.  Pubmed
  4. Kim et al.. Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS. Nature 2013.  Pubmed
  5. Toombs JA, Petri M, Paul KR, Kan GY, Ben-Hur A, Ross ED. De novo design of synthetic prion domains. Proc Natl Acad Sci 2012. Pubmed  Download PDF
  6. Toombs JA, McCarty BR, Ross ED. Compositional determinants of prion formation in yeast. Mol Cell Biol 2010.  Pubmed
  7. Ross ED, Edskes HK, Terry MJ, Wickner RB. Primary sequence independence for prion formation. Proc Natl Acad Sci 2005.  Pubmed
  8. Ross ED, Baxa U, Wickner RB. Scrambled prion domains form prions and amyloid. Mol Cell Biol 2004.  Pubmed
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