{"id":89,"date":"2021-12-08T14:58:45","date_gmt":"2021-12-08T14:58:45","guid":{"rendered":"http:\/\/localhost:81\/wordpress\/?page_id=89"},"modified":"2025-09-22T23:13:06","modified_gmt":"2025-09-22T23:13:06","slug":"home","status":"publish","type":"page","link":"https:\/\/rosslab.colostate.edu\/","title":{"rendered":"Home"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"89\" class=\"elementor elementor-89\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-c641aac elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"c641aac\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-4693784\" data-id=\"4693784\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-31b1e1a elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"31b1e1a\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-acfe682\" data-id=\"acfe682\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-818c1fc elementor-widget elementor-widget-heading\" data-id=\"818c1fc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Update<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-da343e8 elementor-widget elementor-widget-text-editor\" data-id=\"da343e8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-size: inherit; text-align: inherit; color: var( --e-global-color-text );\">Our review is now officially published in the\u00a0<em>Journal of Biological Chemistry<\/em>! While the sequence of amino acids is a critical determinant of how a protein folds and behaves, some proteins play by a different ruleset. These proteins have &#8220;composition-driven activities&#8221;, where the amino acid composition is a stronger determinant of the activity than the linear sequence of amino acids. This review discusses known examples of composition-driven activities, as well as experimental criteria for classifying activities as composition-driven. You can read the paper <span style=\"text-decoration: underline;\"><strong><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40885394\/\" target=\"_blank\" rel=\"noopener\">here<\/a><\/strong><\/span>.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0ce4259 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"0ce4259\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c8d2bf2 elementor-widget elementor-widget-text-editor\" data-id=\"c8d2bf2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>The Ross Lab is in the department of Biochemistry and Molecular Biology at Colorado State University. Our primary research interests involve prions and prion-like proteins, although we are also actively investigating the functions, structures, and regulation of low-complexity domains within proteins.<\/p><p>Our primary research toolkit includes:<\/p><ul><li>Yeast genetics<\/li><li>Fluorescence microscopy<\/li><li>Protein purification and\u00a0<em>in vitro<\/em>\u00a0biochemistry<\/li><li>Bioinformatics<\/li><\/ul><p>Go to the <strong><a title=\"Research Interests\" href=\"https:\/\/rosslab.colostate.edu\/?page_id=23\">Research Interests<\/a><\/strong>\u00a0tab to read more about what we do.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-f328ecd\" data-id=\"f328ecd\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8512a97 elementor-widget elementor-widget-image\" data-id=\"8512a97\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"676\" height=\"493\" src=\"https:\/\/rosslab.colostate.edu\/wp-content\/uploads\/2021\/12\/Github_and_Lab_Logo-01-1024x747.jpg\" class=\"attachment-large size-large wp-image-314\" alt=\"\" srcset=\"https:\/\/rosslab.colostate.edu\/wp-content\/uploads\/2021\/12\/Github_and_Lab_Logo-01-1024x747.jpg 1024w, https:\/\/rosslab.colostate.edu\/wp-content\/uploads\/2021\/12\/Github_and_Lab_Logo-01-300x219.jpg 300w, https:\/\/rosslab.colostate.edu\/wp-content\/uploads\/2021\/12\/Github_and_Lab_Logo-01-768x560.jpg 768w, https:\/\/rosslab.colostate.edu\/wp-content\/uploads\/2021\/12\/Github_and_Lab_Logo-01-1536x1120.jpg 1536w, https:\/\/rosslab.colostate.edu\/wp-content\/uploads\/2021\/12\/Github_and_Lab_Logo-01-2048x1494.jpg 2048w, https:\/\/rosslab.colostate.edu\/wp-content\/uploads\/2021\/12\/Github_and_Lab_Logo-01-676x493.jpg 676w\" sizes=\"(max-width: 676px) 100vw, 676px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6bc814a elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6bc814a\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-36bdcb1\" data-id=\"36bdcb1\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-25a6c0f elementor-widget elementor-widget-spacer\" data-id=\"25a6c0f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Update Our review is now officially published in the\u00a0Journal of Biological Chemistry! While the sequence of amino acids is a critical determinant of how a protein folds and behaves, some [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"template-fullwidth.php","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":["post-89","page","type-page","status-publish","hentry","post-preview"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 4.9.9 - aioseo.com -->\n\t<meta name=\"description\" content=\"Welcome to the Ross lab, where we explore protein &quot;low-complexity&quot; domains and their role in cellular stress responses, protein aggregation, and disease.\" \/>\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<link rel=\"canonical\" href=\"https:\/\/rosslab.colostate.edu\/\" \/>\n\t<meta name=\"generator\" content=\"All in One SEO (AIOSEO) 4.9.9\" \/>\n\t\t<meta property=\"og:locale\" content=\"en_US\" \/>\n\t\t<meta property=\"og:site_name\" content=\"Ross Lab -\" \/>\n\t\t<meta property=\"og:type\" content=\"website\" \/>\n\t\t<meta property=\"og:title\" content=\"Ross Lab - Colorado State University\" \/>\n\t\t<meta property=\"og:description\" content=\"Welcome to the Ross lab, where we explore protein &quot;low-complexity&quot; domains and their role in cellular stress responses, protein aggregation, and disease.\" \/>\n\t\t<meta property=\"og:url\" content=\"https:\/\/rosslab.colostate.edu\/\" \/>\n\t\t<meta name=\"twitter:card\" content=\"summary\" \/>\n\t\t<meta name=\"twitter:title\" content=\"Ross Lab - Colorado State University\" \/>\n\t\t<meta name=\"twitter:description\" content=\"Welcome to the Ross lab, where we explore protein &quot;low-complexity&quot; domains and their role in cellular stress responses, protein aggregation, and disease.\" \/>\n\t\t<script type=\"application\/ld+json\" class=\"aioseo-schema\">\n\t\t\t{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/rosslab.colostate.edu\\\/#breadcrumblist\",\"itemListElement\":[{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/rosslab.colostate.edu#listItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/rosslab.colostate.edu\",\"nextItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/rosslab.colostate.edu\\\/#listItem\",\"name\":\"Home\"}},{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/rosslab.colostate.edu\\\/#listItem\",\"position\":2,\"name\":\"Home\",\"previousItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/rosslab.colostate.edu#listItem\",\"name\":\"Home\"}}]},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/rosslab.colostate.edu\\\/#organization\",\"name\":\"Ross Lab\",\"url\":\"https:\\\/\\\/rosslab.colostate.edu\\\/\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/rosslab.colostate.edu\\\/#webpage\",\"url\":\"https:\\\/\\\/rosslab.colostate.edu\\\/\",\"name\":\"Ross Lab - Colorado State University\",\"description\":\"Welcome to the Ross lab, where we explore protein \\\"low-complexity\\\" domains and their role in cellular stress responses, protein aggregation, and disease.\",\"inLanguage\":\"en-US\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/rosslab.colostate.edu\\\/#website\"},\"breadcrumb\":{\"@id\":\"https:\\\/\\\/rosslab.colostate.edu\\\/#breadcrumblist\"},\"datePublished\":\"2021-12-08T14:58:45+00:00\",\"dateModified\":\"2025-09-22T23:13:06+00:00\"},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/rosslab.colostate.edu\\\/#website\",\"url\":\"https:\\\/\\\/rosslab.colostate.edu\\\/\",\"name\":\"Ross Lab\",\"inLanguage\":\"en-US\",\"publisher\":{\"@id\":\"https:\\\/\\\/rosslab.colostate.edu\\\/#organization\"}}]}\n\t\t<\/script>\n\t\t<!-- All in One SEO -->\n\n","aioseo_head_json":{"title":"Ross Lab - Colorado State University","description":"Welcome to the Ross lab, where we explore protein \"low-complexity\" domains and their role in cellular stress responses, protein aggregation, and disease.","canonical_url":"https:\/\/rosslab.colostate.edu\/","robots":"max-image-preview:large","keywords":"","webmasterTools":{"miscellaneous":""},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"BreadcrumbList","@id":"https:\/\/rosslab.colostate.edu\/#breadcrumblist","itemListElement":[{"@type":"ListItem","@id":"https:\/\/rosslab.colostate.edu#listItem","position":1,"name":"Home","item":"https:\/\/rosslab.colostate.edu","nextItem":{"@type":"ListItem","@id":"https:\/\/rosslab.colostate.edu\/#listItem","name":"Home"}},{"@type":"ListItem","@id":"https:\/\/rosslab.colostate.edu\/#listItem","position":2,"name":"Home","previousItem":{"@type":"ListItem","@id":"https:\/\/rosslab.colostate.edu#listItem","name":"Home"}}]},{"@type":"Organization","@id":"https:\/\/rosslab.colostate.edu\/#organization","name":"Ross Lab","url":"https:\/\/rosslab.colostate.edu\/"},{"@type":"WebPage","@id":"https:\/\/rosslab.colostate.edu\/#webpage","url":"https:\/\/rosslab.colostate.edu\/","name":"Ross Lab - Colorado State University","description":"Welcome to the Ross lab, where we explore protein \"low-complexity\" domains and their role in cellular stress responses, protein aggregation, and disease.","inLanguage":"en-US","isPartOf":{"@id":"https:\/\/rosslab.colostate.edu\/#website"},"breadcrumb":{"@id":"https:\/\/rosslab.colostate.edu\/#breadcrumblist"},"datePublished":"2021-12-08T14:58:45+00:00","dateModified":"2025-09-22T23:13:06+00:00"},{"@type":"WebSite","@id":"https:\/\/rosslab.colostate.edu\/#website","url":"https:\/\/rosslab.colostate.edu\/","name":"Ross Lab","inLanguage":"en-US","publisher":{"@id":"https:\/\/rosslab.colostate.edu\/#organization"}}]},"og:locale":"en_US","og:site_name":"Ross Lab -","og:type":"website","og:title":"Ross Lab - Colorado State University","og:description":"Welcome to the Ross lab, where we explore protein &quot;low-complexity&quot; domains and their role in cellular stress responses, protein aggregation, and disease.","og:url":"https:\/\/rosslab.colostate.edu\/","twitter:card":"summary","twitter:title":"Ross Lab - Colorado State University","twitter:description":"Welcome to the Ross lab, where we explore protein &quot;low-complexity&quot; domains and their role in cellular stress responses, protein aggregation, and disease."},"aioseo_meta_data":{"post_id":"89","title":"#site_title #separator_sa #tagline Colorado State University","description":"#tagline Welcome to the Ross lab, where we explore protein \"low-complexity\" domains and their role in cellular stress responses, protein aggregation, and disease.","keywords":[],"keyphrases":{"focus":{"keyphrase":"","score":0,"analysis":{"keyphraseInTitle":{"score":0,"maxScore":9,"error":1}}},"additional":[]},"primary_term":null,"canonical_url":null,"og_title":null,"og_description":null,"og_object_type":"website","og_image_type":"default","og_image_url":null,"og_image_width":null,"og_image_height":null,"og_image_custom_url":null,"og_image_custom_fields":null,"og_video":"","og_custom_url":null,"og_article_section":null,"og_article_tags":[],"twitter_use_og":false,"twitter_card":"default","twitter_image_type":"default","twitter_image_url":null,"twitter_image_custom_url":null,"twitter_image_custom_fields":null,"twitter_title":null,"twitter_description":null,"schema":{"blockGraphs":[],"customGraphs":[],"default":{"data":{"Article":[],"Course":[],"Dataset":[],"FAQPage":[],"Movie":[],"Person":[],"Product":[],"ProductReview":[],"Car":[],"Recipe":[],"Service":[],"SoftwareApplication":[],"WebPage":[]},"graphName":"WebPage","isEnabled":true},"graphs":[],"defaultGraph":"","defaultPostTypeGraph":""},"schema_type":"default","schema_type_options":null,"pillar_content":false,"robots_default":true,"robots_noindex":false,"robots_noarchive":false,"robots_nosnippet":false,"robots_nofollow":false,"robots_noimageindex":false,"robots_noodp":false,"robots_notranslate":false,"robots_max_snippet":"-1","robots_max_videopreview":"-1","robots_max_imagepreview":"large","priority":null,"frequency":"default","local_seo":null,"breadcrumb_settings":null,"limit_modified_date":false,"ai":null,"created":"2022-04-04 17:51:25","updated":"2025-09-22 23:14:24","seo_analyzer_scan_date":null},"aioseo_breadcrumb":"<div class=\"aioseo-breadcrumbs\"><span class=\"aioseo-breadcrumb\">\n\t\t\t<a href=\"https:\/\/rosslab.colostate.edu\" title=\"Home\">Home<\/a>\n\t\t<\/span><span class=\"aioseo-breadcrumb-separator\">&raquo;<\/span><span class=\"aioseo-breadcrumb\">\n\t\t\tHome\n\t\t<\/span><\/div>","aioseo_breadcrumb_json":[{"label":"Home","link":"https:\/\/rosslab.colostate.edu"},{"label":"Home","link":"https:\/\/rosslab.colostate.edu\/"}],"_links":{"self":[{"href":"https:\/\/rosslab.colostate.edu\/index.php?rest_route=\/wp\/v2\/pages\/89","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/rosslab.colostate.edu\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/rosslab.colostate.edu\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/rosslab.colostate.edu\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/rosslab.colostate.edu\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=89"}],"version-history":[{"count":73,"href":"https:\/\/rosslab.colostate.edu\/index.php?rest_route=\/wp\/v2\/pages\/89\/revisions"}],"predecessor-version":[{"id":554,"href":"https:\/\/rosslab.colostate.edu\/index.php?rest_route=\/wp\/v2\/pages\/89\/revisions\/554"}],"wp:attachment":[{"href":"https:\/\/rosslab.colostate.edu\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=89"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}